Patient Resources for
Postpartum Depression (PPD)
Postpartum Depression (PPD) can affect a mother’s ability to care for her child and may negatively affect a child’s cognitive development. PPD is thought to develop from rapid changes in the levels of endogenous neurosteroids during pregnancy.
Plasma levels of allopregnanolone, which is a metabolite of progesterone and GABA modulator, are known to increase throughout pregnancy and then precipitously drop after delivery. It is thought that these rapid hormonal changes are linked to triggering depression in women who are vulnerable to develop this condition.
The most common medications prescribed to women who seek treatment for PPD are SSRI’s and SNRI’s, which have limited evidence of efficacy. There are currently no approved therapies to treat PPD.
How does PPD affect the body?
PPD is a mood disorder that affects about 15% of women within the first year of childbirth. Women with PPD experience feelings of extreme sadness, hopelessness, suicidal ideation, anxiety, and fatigue. These symptoms mirror those of a major depressive episode with the additional criteria that the onset of depression occurs within 4 weeks of childbirth. PPD can affect a mother’s ability to care for her child and may negatively affect a child’s cognitive development.
Where can I find more information on PDD?
You can find additional educational and support resources on Postpartum Depression through the following foundations and patient advocacy groups:
Links to third party sites are provided for convenience purposes only. The information contained on these sites is not information provided, controlled or monitored by Marinus Pharmaceuticals in any way. Marinus Pharmaceuticals is not responsible in any way for the accuracy, completeness or fitness for any particular purpose of any content appearing on such sites.