CDKL5 Deficiency Disorder

Our mission: Fight for children with CDKL5 deficiency disorder and their families.

At Marinus, we ally with our healthcare partners and advocacy groups because we care about our patients’ lives, stories, and voices.

What is CDKL5 Deficiency Disorder?

CDKL5 deficiency disorder (CDD) is a serious and rare genetic disorder that is caused by a mutation of the cyclin-dependent kinase-like 5 (CDKL5) gene, which is located on the X chromosome and encodes proteins essential for normal brain function. CDD predominantly affects females and is characterized by early-onset, difficult-to-control seizures and severe neuro-developmental impairment. Many children diagnosed with CDD also experience scoliosis, visual impairment, sensory problems, gastrointestinal difficulties, and sleeping disorders.

It is estimated that there are 90 – 100 babies born with CDD in the U.S. every year.

Young Girl Teddy Heart Physician

Learn more about CDKL5 Deficiency Disorder

Download this infographic to learn more about CDKL5 Deficiency Disorder

Additional educational and support resources:

International Foundation for CDKL5 Research

CDKL5 Alliance

CDKL5 Research Collaborative

Loulou Foundation


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Partridge Family Cdlk5 1

Patient Story:

CDKL5 Deficiency Disorder: Partridge Family